An unusual MHC molecule generates protective CD8+ T cell responses to chronic infection
A. Tsitsiklis, D. J. Bangs, L. L. Lutes, S.-W. Chan, K. Geiger, A. J. Modzelewski, L. Labarta-Bajo, Y. Wang, E. I. Zuniga, S. Dai, E. A. Robey
This study shows that an unusual MHC-1 molecule, Ld, with limited peptide binding generates more protective and less exhausted CD8+ T cell responses against chronic Toxoplasma gondii infection.
bioRxiv · Feb 3, 2020Immunology