S. Dai

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

This study shows miR-574-5p activates TLR8 to drive autoimmune signaling and lupus progression by enhancing cytokine production, STAT1 activation, and autoantigen generation.

Heat Shock Factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat-shock response

This study shows HSF1 enhances c-MYC transcription independently of the heat-shock response by recruiting GCN5 to promote histone acetylation.

A cell type-specific multiomics uncovers a guard cell-specific RAF15-SnRK2.6/OST1 kinase cascade

The paper develops a cell type-specific multiomics pipeline to analyze guard cells and mesophyll cells, revealing a kinase cascade involved in ABA-induced stomatal closure.

The Clusters of Transcription Factors NFATC2, STAT5, GATA2, AP1,RUNX1 and EGR2 Binding Sites at the Induced Il13 Enhancers Mediate Il13 Gene Transcription in Response to Antigenic Stimulation

This study identifies Il13 enhancers that mediate gene transcription in response to antigenic stimulation by analyzing histone modifications and transcription factor binding sites.

Mainly on the Plane: Deep Subsurface Bacterial Proteins Bind and Alter Clathrate Structure

The paper identifies bacterial proteins that bind to gas clathrates and alter their morphology, suggesting potential industrial applications for clathrate control.

Novel Vβ specific germline contacts shape an elite controller T cell response

The paper identifies Vβ2-specific germline contacts that contribute to a focused T cell response against a parasite-derived peptide presented by H-2Ld, enhancing HIV control.

An unusual MHC molecule generates protective CD8+ T cell responses to chronic infection

This study shows that an unusual MHC-1 molecule, Ld, with limited peptide binding generates more protective and less exhausted CD8+ T cell responses against chronic Toxoplasma gondii infection.

Interleukin-22 drives a metabolic adaptive reprogramming to maintain mitochondrial fitness and treat liver injury

This study shows IL-22 improves liver injury by promoting metabolic reprogramming and mitochondrial function through a signaling pathway involving AMPK, AKT, and mTOR.

Dscam homophilic specificity is generated by high order cis-multimers coupled with trans self-binding of variable Ig1 in Chelicerata

The paper shows that Dscam isoforms in Chelicerata form cis-multimers and trans-self-bind via Ig1 domains to generate unique homophilic recognition specificities for neuronal self-avoidance.

Na2CO3-Responsive Photosynthetic and ROS Scavenging Mechanisms in Chloroplasts of Alkaligrass Revealed by Phosphoproteomics

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

Accelerated Protein Biomarker Discovery from FFPE tissue samples using Single-shot, Short Gradient Microflow SWATH MS

This paper introduces an accelerated SWATH MS method for protein biomarker discovery in FFPE tissues, showing reduced instrument time and batch effects while maintaining good protein quantification and clinical separation.