E. A. Robey

Commensal Bacteria Maintain a Qa-1b-restricted Unconventional CD8+ T Population in Gut Epithelium

The paper identifies Qa-1b-restricted CD8+ T cells in the gut epithelium, showing they depend on commensal bacteria for maintenance.

Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes

This study shows that Fam49b suppresses TCR signaling to prevent excessive negative selection in thymocytes, ensuring normal T cell development.

Thymic macrophages consist of two populations with distinct localization and origin

This study identifies two distinct thymic macrophage populations with different locations and origins using single-cell RNA sequencing and genetic fate mapping.

Novel Vβ specific germline contacts shape an elite controller T cell response

The paper identifies Vβ2-specific germline contacts that contribute to a focused T cell response against a parasite-derived peptide presented by H-2Ld, enhancing HIV control.

An unusual MHC molecule generates protective CD8+ T cell responses to chronic infection

This study shows that an unusual MHC-1 molecule, Ld, with limited peptide binding generates more protective and less exhausted CD8+ T cell responses against chronic Toxoplasma gondii infection.

Factors that influence the thymic selection of CD8αα intraepithelial lymphocytes

The paper investigates factors influencing thymic selection of CD8αα intraepithelial lymphocytes, finding that CD8 IEL development requires a higher TCR affinity threshold than negative selection.

A role for phagocytosis in inducing cell death during thymocyte negative selection

This study shows that phagocytosis enhances negative selection of autoreactive thymocytes by promoting their death, with more efficient elimination when phagocytes also present the negative selecting peptide.