Cancer BiologybioRxiv
Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone.
L. Cottone, L. Ligammari, H. J. Knowles…·A. M. Flanagan
This study identifies aberrant paracrine signaling between osteoprogenitors and osteoclasts driven by H3.3 mutations as a mechanism underlying giant cell tumor of bone and its response to treatment.
DOI 10.1038/s41418-022-01031-x