Cancer BiologybioRxiv
DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forks
K. Venugopal, P. Nowialis, Y. Feng…·O. A. Guryanova
This study shows that DNMT3A mutations impair replication fork recovery, leading to DNA damage and sensitivity to nucleoside analogs like cytarabine.
DOI 10.1158/1078-0432.ccr-21-2863