A. Riva

Effects of SGLT2 Ablation or Inhibition on Corticosterone Secretion in High-Fat-Fed Mice: Exploring a Nexus with Cytokine Levels

This study investigates the effects of SGLT2 inhibition or deletion on corticosterone secretion and cytokine levels in high-fat-fed mice, revealing links between SGLT2 activity, immune modulation, and metabolic homeostasis.

Broad diversity of human gut bacteria accessible via a traceable strain deposition system

The paper establishes a publicly available collection of 340 human gut bacterial strains, including 29 newly described species, and identifies plasmids and megaplasmids within these isolates.

KDM6A Regulates Immune Response Genes in Multiple Myeloma

This study shows KDM6A regulates immune response genes in multiple myeloma by activating NLRC5 and CIITA, and its loss reduces MHC expression, which can be reversed by HDAC3 inhibitors.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Heterogeneous Nuclear Ribonucleoprotein C is an Indispensable Target in Acute Myeloid Leukemia

This study identifies HNRNPC as a critical therapeutic target in AML by showing its role in regulating Myc-Max activity through alternative splicing.

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer

This study shows that hematopoietic Dnmt3a haploinsufficiency worsens colitis-associated colon cancer by promoting angiogenesis, which can be targeted with axitinib.

Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight

The paper uses FENGC to analyze spaceflight-induced DNA methylation changes in Arabidopsis roots, identifying novel methylation-regulated genes involved in root growth.

Flap-enabled next-generation capture (FENGC): precision targeted single-molecule profiling of epigenetic heterogeneity, chromatin dynamics, and genetic variation

FENGC enables precise, cost-effective targeted sequencing of genetic and epigenetic features by using flap endonuclease to enrich for specific sequences.

HDAC8-mediated inhibition of EP300 drives a neural crest-like transcriptional state that increases melanoma brain metastasis

Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

The paper examines the kinetics, avidity, and cross-reactivity of SARS-CoV-2-specific memory B cells and antibodies in infected and vaccinated individuals over 16 months, finding that MBC maturation enhances resilience to viral escape.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

This study shows that Omicron variant's spike protein has enhanced ACE2 binding and reduces neutralizing activity, but some broadly neutralizing antibodies remain effective.

DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forks

This study shows that DNMT3A mutations impair replication fork recovery, leading to DNA damage and sensitivity to nucleoside analogs like cytarabine.

A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery

This paper identifies a human antibody that broadly neutralizes betacoronaviruses by targeting the stem helix, showing protection against SARS-CoV-2 and potential for vaccine design.

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

The paper identifies a conserved antigenic supersite on the SARS-CoV-2 N-terminal domain recognized by neutralizing antibodies and shows its vulnerability to mutations in variants.

Brain tissue transcriptomic analysis of SIV-infected macaques identifies several altered metabolic pathways linked to neuropathogenesis, and Poly (ADP-ribose) polymerases (PARPs) as potential therapeutic targets

This study analyzes transcriptomic data from SIV-infected macaques to identify altered metabolic pathways and PARPs as potential therapeutic targets in HIV-associated neurodegeneration.