L. Moroni

RAVEN: development of a novel volumetric extrusion-based system for small-scale Additive Manufacturing

The paper introduces RAVEN, a novel volumetric extrusion-based AM system for small-scale fabrication, demonstrating its potential for advanced applications like in vivo bioprinting.

Hypotrochoidal scaffolds for cartilage regeneration

This study develops hypotrochoidal scaffolds for cartilage regeneration, showing improved mechanical properties and collagen II deposition compared to traditional woodpile designs.

Soft, dynamic hydrogel confinement improves kidney organoid lumen morphology and reduces epithelial-mesenchymal transition in culture

This study shows that soft, dynamic hydrogels improve kidney organoid morphology and reduce epithelial-mesenchymal transition compared to stiff hydrogels.

Effect of reduced graphene oxide (rGO) compaction degree and concentration on rGO-polymer composites printability and cell interactions

Additive manufactured scaffolds for bone tissue engineering: physical characterization of thermoplastic composites with functional fillers

The paper characterizes the rheological and mechanical properties of thermoplastic composites for bone tissue engineering scaffolds and develops computational models to predict scaffold elastic moduli.

3D soft hydrogels induce human mesenchymal stem cells "deep" quiescence

This paper shows that 3D alginate hydrogels induce a deep quiescent state in hMSCs, characterized by cell cycle arrest and upregulated quiescence markers, unlike 2D cultures.

Effect of Highly Loaded Nanohydroxyapatite Composite Scaffolds Prepared via Melt Extrusion Additive Manufacturing on the Osteogenic Differentiation of Human Mesenchymal Stromal Cells

This study evaluates the osteogenic potential of highly loaded nanohydroxyapatite scaffolds fabricated via melt extrusion additive manufacturing, showing enhanced mechanical properties and potential for in vitro and in vivo osteoinduction.

Mimicking the Human Tympanic Membrane: the Significance of Geometry

This paper investigates how the geometry of tissue-engineered tympanic membranes affects their mechanical and acoustic properties using computational models and experimental tests.

A hybrid additive manufacturing platform to create bulk and surface composition gradients on scaffolds for tissue regeneration

This paper introduces a hybrid additive manufacturing platform that creates continuous composition gradients and selectively modifies scaffold surfaces to enhance cell adhesion.

3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration

This study develops 3D scaffolds with antibiotic-loaded inorganic fillers for bone infection prevention and tissue regeneration, showing sustained antibiotic release and compatibility with cell differentiation.

Full cell infiltration and thick tissue formation in vivo in tailored electrospun scaffolds

This paper develops a method to enhance cell infiltration in electrospun scaffolds by modifying fiber diameter and co-spinning sacrificial fibers, achieving full tissue infiltration in vivo.

A one-step biofunctionalization strategy of electrospun scaffolds enables spatially selective presentation of biological cues

This paper introduces a one-step method to functionalize scaffolds with spatially selective biological cues, showing differential neurite growth in dorsal root ganglia.

Meso-scale multi-material fabrication of a Synthetic ECM Mimic for In vivo-like Peripheral Nerve Regeneration

This paper develops a synthetic ECM mimic with meso- and nanoscale features to promote in vitro neurite growth and mimic peripheral nerve regeneration.

Tandem electrospinning for heterogeneous nanofiber patterns

This paper introduces Tandem Electrospinning (T-ESP), a novel technique for creating complex, patterned nanofibrous constructs with spatially defined heterogeneity.

Improving cell distribution on 3D additive manufactured scaffolds through engineered seeding media density and viscosity

This study improves cell distribution on 3D scaffolds by adjusting seeding media viscosity and density using dextran and Ficoll, enhancing cell attachment and matrix production.

Mechanosensitive regulation of FGFR1 through the MRTF-SRF pathway

This study shows that hMSCs downregulate FGFR1 through the MRTF/SRF pathway when cultured on microfibrillar substrates, making them unresponsive to bFGF, unlike fibroblasts.

Dimensionality changes actin network through lamin A and C and zyxin

This study shows that dimensionality affects the actin cytoskeleton in hMSCs via lamin A/C and zyxin, impacting stress fibers and nuclear localization.