R. Sinha

Atlas of Cynomolgus Macaque Hematopoiesis

The paper develops a single-cell transcriptomic map of cynomolgus macaque hematopoietic stem cells and progenitors, revealing molecular differences from humans and a direct differentiation pathway to megakaryocyte lineages.

Fitness Factor Genes Conserved within the Multi-species Core Genome of Gram-negative Enterobacterales Species Contribute to Bacteremia Pathogenesis

The paper identifies 18 conserved fitness genes in Enterobacterales species that contribute to bacteremia pathogenesis by testing mutants in a mouse model and finding attenuation in multiple organs.

NK and NKT cells in the pathogenesis of Hidradenitis suppurativa: Novel therapeutic strategy through targeting of CD2

This study identifies expanded NKT and NK cells with elevated CD2 in HS lesions and shows CD2 blockade reduces inflammation and fibrosis.

Gut metabolite L-lactate supports Campylobacter jejuni population expansion during acute infection

This study identifies L-lactate as a key metabolite supporting Campylobacter jejuni growth during acute infection in ferrets, revealing a regulatory mechanism involving the LctR protein.

Integrative phenotypic-transcriptomic analysis of soybean plants subjected to multifactorial stress combination

This study investigates the effects of multifactorial stress combinations on soybean plants, revealing negative cumulative impacts and unique transcriptomic responses in different tissues.

Employing Deep Learning Model to Evaluate Speech Information in Vocoder Simulations of Auditory Implants

This study uses a deep learning speech recognition model to evaluate speech perception in vocoder simulations of cochlear implants, showing human-like robustness and cost-effectiveness.

The transcriptome of soybean reproductive tissues subjected to water deficit, heat stress, and a combination of water deficit and heat stress.

This study presents a transcriptomic dataset of soybean reproductive tissues under water deficit, heat stress, and their combination, revealing unique stress responses across tissues.

The effects of multifactorial stress combination on rice and maize

This study shows that multifactorial stress combinations negatively affect rice and maize growth, with proteomics revealing common stress-responsive proteins.

Differential transpiration between pods and leaves during stress combination in soybean

The paper shows that soybean pods and leaves exhibit differential transpiration under combined water deficit and heat stress, reducing internal pod temperature and protecting seed development.

An essential host dietary fatty acid promotes TcpH inhibition of TcpP proteolysis enabling virulence gene expression in Vibrio cholerae

A blunted GPR183/oxysterol axis during dysglycemia results in delayed recruitment of macrophages to the lung during M. tuberculosis infection

This study shows that dysglycemia impairs the GPR183/oxysterol axis, leading to delayed macrophage recruitment and worsened tuberculosis outcomes in mice.

Differential regulation of flower transpiration during abiotic stress in plants

The paper shows that under drought and heat stress, soybean plants open flower stomata to lower flower temperature, protecting reproduction at the expense of vegetative tissues.

Dysregulated Protein Translation Control in Hidradenitis Suppurativa: Implication for Lesion-associated Squamous Cell Carcinoma Development

This study identifies dysregulated eIF4F translation initiation complex in HS lesions, linking it to SCC development through Cyclin D1 and c-Myc overexpression.

Ex Vivo Culture Models of Hidradenitis Suppurativa for defining molecular pathogenesis and treatment efficacy of novel drugs

This paper develops three ex vivo skin culture models for HS to study molecular pathogenesis and drug efficacy.

ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling

The paper identifies how apoE4 disrupts sortilin-FABP7 interactions, impairing lipid signaling and contributing to Alzheimer's disease pathology.

Effect of reduced graphene oxide (rGO) compaction degree and concentration on rGO-polymer composites printability and cell interactions

Pre-diabetes increases tuberculosis disease severity, while high body fat without impaired glucose tolerance is protective

Additive manufactured scaffolds for bone tissue engineering: physical characterization of thermoplastic composites with functional fillers

The paper characterizes the rheological and mechanical properties of thermoplastic composites for bone tissue engineering scaffolds and develops computational models to predict scaffold elastic moduli.

Effect of Highly Loaded Nanohydroxyapatite Composite Scaffolds Prepared via Melt Extrusion Additive Manufacturing on the Osteogenic Differentiation of Human Mesenchymal Stromal Cells

This study evaluates the osteogenic potential of highly loaded nanohydroxyapatite scaffolds fabricated via melt extrusion additive manufacturing, showing enhanced mechanical properties and potential for in vitro and in vivo osteoinduction.

GPR183 regulates interferons and bacterial growth during Mycobacterium tuberculosis infection: interaction with type 2 diabetes and TB disease severity

A hybrid additive manufacturing platform to create bulk and surface composition gradients on scaffolds for tissue regeneration

This paper introduces a hybrid additive manufacturing platform that creates continuous composition gradients and selectively modifies scaffold surfaces to enhance cell adhesion.

3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration

This study develops 3D scaffolds with antibiotic-loaded inorganic fillers for bone infection prevention and tissue regeneration, showing sustained antibiotic release and compatibility with cell differentiation.

Phosphate transporter PstSCAB of Campylobacter jejuni is essential for lactate-dependent growth and colonization in chickens

This study shows that the phosphate transporter PstSCAB is essential for Campylobacter jejuni's growth on lactate and its ability to colonize chickens.

Mass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis

The paper reports a proteomics resource analyzing protein expression in mouse adult and aged hematopoietic stem cells and their progenitors, revealing differential expression and gene regulation.

Improving cell distribution on 3D additive manufactured scaffolds through engineered seeding media density and viscosity

This study improves cell distribution on 3D scaffolds by adjusting seeding media viscosity and density using dextran and Ficoll, enhancing cell attachment and matrix production.

Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5+ mouse long-term hematopoietic stem cells

This paper identifies Neogenin-1 as a marker distinguishing myeloid-biased from balanced Hoxb5+ long-term hematopoietic stem cells in mice, revealing their functional heterogeneity and hierarchical relationship.