Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans
F. Benz, S. Camara-Wilpert, J. Russel, K. G. Wandera, R. Cepaite, M. Ares-Arroyo, J. V. Gomes-Filho, F. Englert, J. Kuehn, S. Gloor, A. Cuenod, M. Aguila-Sans, L. Maccario, A. Egli, L. Randau, , R. Pinilla-Redondo
This study shows type IV-A3 CRISPR-Cas systems use host adaptation machinery to update their CRISPR arrays and interfere with plasmid and phage transfer, supporting their role in plasmid competition.
bioRxiv · Jun 23, 2023 · PreprintMicrobiology