CDC20 determines the sensitivity to spindle assembly checkpoint (SAC) inhibitors
S. Zheng, L. Raz, L. Zhou, Y. Cohen-Sharir, R. Tian, R. Wardenaar, M. J. C. Broekhuis, M. F. Suarez Peredo Rodriguez, S. Wobben, A. van den Brink, P. Bakker, F. Foijer, U. Ben-David
The paper identifies CDC20 expression as a determinant of sensitivity to SAC inhibitors, showing that aneuploid cells with high CDC20 levels are more sensitive to these drugs.
bioRxiv · Dec 21, 2023 · PreprintCancer Biology