L. Zhou

MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

This study shows that MYC and p53 alterations in prostate cancer cooperate via VEGF signaling to suppress T cell activity and immunotherapy responses, and that targeting VEGFR2 can enhance immunotherapy efficacy.

Synchronous assembly of peptide anisosome

This study reports the formation of symmetrical core-shell biomolecular condensates through programmed tetra-peptide libraries and identifies tryptophan's role in structuring these condensates.

Activation of NLRP3 inflammasome/pyroptosis by protease inhibitor atazanavir at high concentrations is mediated through mitochondrial dysfunction

This study shows high concentrations of atazanavir induce mitochondrial dysfunction and NLRP3 inflammasome/pyroptosis in T cells, leading to apoptosis.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

A chemically defined and xeno-free hydrogel system for regenerative medicine.

The paper develops a chemically defined, xeno-free hydrogel system that supports hPSC differentiation into multiple tissue types and improves hepatocyte retention in vivo.

hESCs-derived organoids achieve liver zonation by LSEC modulation

This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.

High Refractive Index Imaging Buffer for Dual Color 3D SMLM Imaging of Thick Samples

This paper develops a high refractive index imaging buffer to improve 3D SMLM imaging depth in thick samples by reducing RI mismatch and enhancing image quality.

Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis

TLR5 deficiency is linked to pulmonary fibrosis due to its role in preventing microbial dysbiosis following lung injury.

Targeting circadian transcriptional programs in triple negative breast cancer through a cis-regulatory mechanism

This paper identifies a cis-regulatory mechanism in triple-negative breast cancer where targeting circadian transcription factors with small molecules represses a circadian transcriptional program, offering a new therapeutic strategy.

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

This study shows that fish CDK2 recruits Dtx4 to ubiquitinate and degrade TBK1, reducing IFN expression and enhancing antiviral resistance.

Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats

This study examines how cardiorespiratory fitness affects epigenetic aging in different organs of rats, finding organ-specific and common changes in DNA methylation.

Tumor suppressor p73 transcriptionally regulates c-FLIP to impede its priming of extrinsic apoptosis while a switcher compound degrades c-FLIP protein

This study shows p73 upregulates c-FLIP to suppress extrinsic apoptosis, and a compound degrades c-FLIP to enhance p73's antitumor effects in p53-mutant cancers.

Aberration correction for deformable mirror based remote focusing enables high-accuracy whole-cell super-resolution imaging

This paper develops a deformable mirror-based remote focusing system to enable high-accuracy whole-cell super-resolution imaging with uniform resolution across thick samples.

An Innovative Mitochondrial-targeted Gene Therapy for Cancer Treatment

This paper introduces mLumiOpto, a mitochondrial-targeted gene therapy that disrupts cancer cell mitochondria using light-activated proteins, showing efficacy in reducing tumor burden in mouse models.

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

Epithelial HO-1 regulates iron availability and promotes colonic tumorigenesis in a context-dependent manner

This study shows that epithelial HO-1 promotes colonic tumorigenesis in chronic inflammation by increasing iron availability and oxidative stress, while protecting against acute heme toxicity.

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

Gut microbes of the cecum versus the colon drive more severe lethality and multi-organ damage

This study compares the severity of sepsis caused by intestinal perforations in the cecum versus colon, finding that cecum perforations lead to more severe outcomes due to higher bacterial burden and pathogenic microbial abundance.

Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing.

This paper develops a zebrafish model for medulloblastoma drug testing, showing that neural stem cell culture conditions enhance tumor cell homing and aggressiveness, enabling high-throughput screening.

Diaminopurine in Nonenzymatic RNA Template Copying

This study investigates whether replacing adenine with diaminopurine in nonenzymatic RNA template copying improves efficiency and reduces bias.

Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess Desulfovibrio through gut-liver axis

The paper shows that restricting sulfur-containing amino acids reduces liver injury caused by excess Desulfovibrio by lowering bile acids and improving liver function.

High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in SHH-medulloblastoma

The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcription

This paper identifies CHMP5 as a nuclear factor that promotes T cell leukemia by enhancing BRD4-p300-dependent transcription at enhancers and super-enhancers.

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

This study develops rod-shaped Janus base nanopieces for improved tissue penetration and therapeutics delivery, showing better efficacy than spherical lipid nanoparticles in ovarian cancer models.

Constraints on the Emergence of RNA through Non-Templated Primer Extension with Mixtures of Potentially Prebiotic Nucleotides

This study investigates non-templated primer extension with alternative nucleotides to determine if RNA synthesis was biased against threo-nucleotides.

Shared Transcriptomic Signatures of Inflammaging Among Diverse Strains of Drosophila melanogaster

The paper identifies shared transcriptomic signatures of inflammaging across Drosophila melanogaster strains and shows machine learning can predict inflammatory age.

Single-cell RNA sequencing reveals recruitment of the M2-like CCL8high macrophages in Lewis lung carcinoma-bearing mice following hypofractionated radiotherapy

This study uses single-cell RNA sequencing to show hypofractionated radiotherapy recruits CCL8high macrophages, reprograms them to an immunosuppressive state, and enhances tumor growth, which can be counteracted by CCL inhibitor Bindarit.

Target-aware Molecule Generation for Drug Design Using a Chemical Language Model

This paper introduces TamGen, a chemical language model for target-aware molecule generation, and shows it produces high-quality compounds with inhibitory activity against Tuberculosis ClpP protease.

Armed Macrophages as Hunters for Photodynamic Therapy of Systemic Bacterial Infections by Bathing in the Sunshine

This paper introduces a 'live drug' called A-RAWs that uses sunlight to treat systemic bacterial infections by capturing bacteria and killing them with photodynamic therapy upon reaching the skin.