S. Zheng

The paper introduces ReSisTrace, a method to identify pre-resistant cell states in cancer by analyzing sister cells, and validates its use in ovarian cancer models.

This paper develops a dual-targeted nanoparticulate drug delivery system (SJNP) combining SN38 and JQ-1 to enhance triple-negative breast cancer treatment by disrupting DNA repair and mitochondrial function.

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

The paper introduces PUP-IT, a pupylation-based proximity labelling method for detecting protein interactions in plants, and identifies BEN1 as a regulator of cellulose synthesis.

The paper identifies CDC20 expression as a determinant of sensitivity to SAC inhibitors, showing that aneuploid cells with high CDC20 levels are more sensitive to these drugs.

This study identifies Edf1 as an essential transcription activator for multiciliogenesis, showing its role in ciliary gene expression and its impact on hydrocephalus in mice.

The paper introduces FAXP, a method combining hydrogel expansion and mass spectrometry for high-resolution proteomics of FFPE tissues, showing improved resolution and efficiency over existing methods.

This study identifies alternative splicing of CD20 mRNA that generates translation-deficient isoforms, contributing to resistance to CD20-directed immunotherapies.

This paper develops a hybrid adipocyte-derived exosome platform for targeted chemo-phototherapy of hepatocellular carcinoma, showing enhanced drug delivery and tumor growth inhibition.

This paper develops a nanomicelle, SANTA FE OXA, that enhances cancer chemotherapy by inducing ferroptosis and reducing systemic toxicity.

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

This study maps residual mechanical stresses in murine brains across age and after hemorrhagic stroke, finding increased stresses with age and reduced stresses post-stroke.

This paper surveys experts in longevity to identify key bottlenecks and solutions, finding that data sharing and regulatory clarity are critical for advancing aging research.

This paper introduces a far-red dye that selectively labels acidic organelles in live cells, enabling multicolor, time-lapse, and super-resolution imaging with improved photostability and compatibility with long-term experiments.

This study shows that the nuclear matrix binding protein AHL22, along with FRS7 and FRS12, represses hypocotyl elongation in Arabidopsis by suppressing SAUR gene expression through chromatin attachment and histone deacetylation.

This study shows virus infection increases toxin production in cyanobacteria and reveals their potential as a source of antiviral compounds.

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

The paper shows N-MYC promotes survival in inv(16) AML by regulating eIF4G1, identifying a novel MYCN enhancer and a new oncogenic role for eIF4G1 in AML.

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.

This study shows that exosomes from BMSCs with miR-124-3p inhibitor reduce LPS-induced endometritis by modulating DUSP6, p-p65, and p-ERK.

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

This study uses spatial transcriptomics to analyze cisplatin-induced nephrotoxicity and regeneration in different kidney segments, identifying distinct molecular responses and biomarkers.

This study shows that PXN phase separation drives focal adhesion assembly and integrin signaling through light-inducible manipulation.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

This paper develops a long-acting GDF15 analog that reduces food intake and body weight in obese monkeys, with potential for clinical obesity treatment.

This paper introduces a transparent ribcage for real-time, cellular-resolution imaging of lung function in health and disease, revealing insights into tumor progression, immune responses, and disease remodeling.

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.