L. Sari

Molecular mechanism underlying SNARE-mediated membrane fusion enlightened by all-atom molecular dynamics simulations

This study uses molecular dynamics simulations to propose a mechanism for SNARE-mediated membrane fusion, emphasizing local molecular events over general membrane properties.

All-atom molecular dynamics simulations of synaptic vesicle fusion I: a glimpse at the primed state

The paper uses molecular dynamics simulations to study the primed state of synaptic vesicles, revealing a spring-loaded configuration of trans-SNARE complexes bound to synaptotagmin-1 and complexin-1.

All protein aggregates will thermodynamically order

The paper develops a statistical mechanical theory predicting that all protein aggregates will thermodynamically order, regardless of sequence or environmental conditions.

Tau local structure shields amyloid motif and controls aggregation propensity

The paper investigates how local structure in tau protein modulates aggregation propensity and how mutations disrupt this structure to trigger amyloid formation.