Z. Hou

MIPDB: A maize image-phenotype database with multi-angle and multi-time characteristics

The paper introduces MIPDB, a maize image-phenotype database with multi-angle and multi-time images, providing a high-quality dataset for deep learning-based phenomics research.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response

Structure of Native Chromatin Fibres Revealed by Cryo-ET in situ

This study reveals the 3D structure of native chromatin fibres in human T-lymphoblasts using cryo-ET, showing a relaxed, variable zigzag organization of nucleosomes.

Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications

This study defines the DNA binding and cleavage mechanisms of Type I-C CRISPR-Cas3 using cryo-EM and identifies anti-CRISPR proteins that inhibit its activity in human cells.

Human receptive endometrial assembloid for deciphering the implantation window

This study develops a human endometrial assembloid model that mimics the receptive endometrium during the implantation window, showing structural and molecular features and hormone responsiveness.

Multi-omics Comparison among Populations of Three Plant Sources of Amomi Fructus

This study compares multi-omics data across three plant sources of Amomi Fructus to identify genetic and transcriptomic differences, including gene flow and metabolic variation between populations.

Extensive diversity of RNA viruses in ticks revealed by metagenomics in northeastern China

The paper uses metagenomics to identify 22 RNA viruses in ticks from northeastern China, revealing novel species and highlighting public health risks from emerging tick-borne viruses.

Pre-assembled Cas9 ribonucleoprotein-mediated gene deletion identifies the carbon catabolite repressor and its target genes in Coprinopsis cinerea

The paper uses CRISPR-based gene deletion to study Cre1's role in carbon catabolite repression in Coprinopsis cinerea, revealing its regulation of plant biomass degradation genes.

Flavivirus prM interacts with MDA5 and MAVS to inhibit RLR antiviral signaling

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

Biological characteristics of two mesenchymal stem cell lines isolated from the umbilical cord and adipose tissue of a neonatal common hippo (Hippopotamus amphibius)

This study isolates and characterizes two mesenchymal stem cell lines from a neonatal common hippo, showing their fibroblastoid morphology, normal karyotype, and stemness markers, with distinct differentiation potentials.

Lessons on fruiting body morphogenesis from genomes and transcriptomes of Agaricomycetes

This paper identifies 921 conserved genes involved in fruiting body morphogenesis across Agaricomycetes fungi and proposes functional hypotheses for many of them.

Biophysical properties of a tau seed

This study characterizes the biophysical properties of tau seeds, showing they are monomeric and can nucleate tau aggregation in vitro and in cells.

SARS-CoV-2 nucleocapsid protein dually regulates innate immune responses

This study shows that SARS-CoV-2 N protein modulates innate immunity by both suppressing and promoting IFN-I and inflammatory responses depending on its dosage.

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation

This study identifies DnaJC7's interaction with tau's beta-turn element to inhibit amyloid formation, suggesting a mechanism for tau aggregation regulation.

Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma

The paper identifies a subpopulation of malignant Schwann cell precursor-like cells in neuroblastoma that connects adrenergic and mesenchymal tumor cells, suggesting intratumoral plasticity mechanisms.

Biochemically diverse CRISPR-Cas9 orthologs

The paper characterizes the biochemical diversity of CRISPR-Cas9 orthologs, identifying varied PAM recognition and gRNA requirements across 79 Cas9 proteins.

PAM recognition by miniature CRISPR nucleases triggersprogrammable double-stranded DNA target cleavage

This study identifies and characterizes miniature CRISPR-Cas nucleases that cleave double-stranded DNA in a PAM-dependent manner, showing their potential for programmable genome editing.

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

Tau local structure shields amyloid motif and controls aggregation propensity

The paper investigates how local structure in tau protein modulates aggregation propensity and how mutations disrupt this structure to trigger amyloid formation.