M. Lin

c-di-GMP modulates ribosome assembly by inhibiting rRNA methylation

This study shows c-di-GMP inhibits rRNA methylation by binding to RlmI, modulates ribosome assembly, and promotes antibiotic tolerance in E. coli.

Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

This paper identifies AhCobQ as a novel NAD+- and Zn2+-independent lysine deacetylase in Aeromonas hydrophila with unique domain and substrate specificity.

Synergistic and antagonistic drug interactions are prevalent but not conserved across acute myeloid leukemia cell lines

This study investigates drug-drug interactions in AML cell lines, finding widespread but non-conserved synergistic and antagonistic effects across different cell lines.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Aurora Kinase A Inhibition plus Tumor Treating Fields Suppress Glioma Cell Proliferation in a Cilium-Independent Manner

This paper shows that combining Aurora Kinase A inhibition with Tumor Treating Fields reduces glioma cell proliferation, and this effect is not dependent on cilia.

CZ CELLxGENE Discover: A single-cell data platform for scalable exploration, analysis and modeling of aggregated data

CZ CELLxGENE Discover provides a platform for scalable exploration and analysis of aggregated single-cell transcriptomic data across multiple studies.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

PFAS assessment in fish: samples from Illinois waters

This study assesses PFAS levels in fish from Illinois waterways, finding elevated concentrations in specific areas and species, with implications for human health risks through fish consumption.

In vitro toxicity of LiTFSI on Human Renal and Hepatoma Cells

This study evaluates the cytotoxicity and molecular effects of LiTFSI on human renal and hepatoma cells, finding it less toxic than PFOS and affecting redox, apoptosis, and DNA methylation.

Evolution of the mutation spectrum across a mammalian phylogeny

The paper quantifies mutation spectrum variation across mammalian species and finds that genetic divergence, not life history traits, best explains mutation spectrum divergence.

Progressive Senescence Programs Induce Intrinsic Vulnerability to Aging-related Breast Cancer

This study identifies progressive senescence programs in mammary cells that increase vulnerability to aging-related breast cancer and presents a drug to mitigate this risk.

A maturation defective HIV-1 activates cGAS

The paper shows that a maturation-defective HIV-1 variant activates the cGAS pathway, leading to an IFN response due to exposed viral DNA.

Insights into the Microbial Weathering of Chinese Wooden Ancestral Halls in Guangdong Province

The paper analyzes microbial diversity in ancestral halls in Guangdong Province, identifying cellulose- and lignin-degrading microbes and evaluating biocides for wood preservation.

Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain

This paper introduces KiMBIs, bioluminescent indicators that enable non-invasive imaging of kinase inhibitor activity in the brain, identifying temuterkib as a promising brain-active ERK inhibitor.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Smart squirrels use a mortise-tenon structure to fix nuts on understory twigs

The paper describes how two species of flying squirrels in Hainan Island use a mortise-tenon structure to securely cache nuts on twigs to deter predation and ensure food supply.

Mutation in the matricellular gene fibulin-4 leads to endothelial dysfunction in resistance arteries

This study shows that fibulin-4 mutations cause endothelial dysfunction in resistance arteries due to increased shear stress and oxidative environment.

Core genes can have higher recombination rates than accessory genes within global microbial populations

The paper measures recombination rates in core and accessory genes across 12 microbial species using whole genome sequences, finding core genes have higher recombination rates and shorter coalescence times.

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

TNFAIP8 is a novel phosphoinositide-binding inhibitory regulator of Rho GTPases that promotes cancer cell migration

This study identifies TNFAIP8 as a phosphoinositide-binding regulator of Rho GTPases that promotes cancer cell migration by linking inflammation to phosphoinositide signaling.

Single-cell transcriptomics reveal cell type-specific molecular changes and altered intercellular communications in chronic obstructive pulmonary disease

This study uses single-cell RNA sequencing to identify cell type-specific molecular changes and altered intercellular communications in COPD, linking them to alveolar epithelial dysfunction.

In vivo generation of BK and JC polyomavirus defective viral genomes in human urine samples associated with higher viral loads

The paper identifies defective viral genomes (DVGs) in clinical urine samples of BK and JC polyomaviruses, showing their association with higher viral loads and genomic rearrangements.

Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude

The paper uses optical tools to show that RhoA activation levels determine distinct cellular responses, with low levels causing focal adhesion disassembly and high levels causing both growth and disassembly.

From zero to infinity: minimum to maximum diversity of the planet by spatio-parametric Rao's quadratic entropy

This paper generalizes Rao's quadratic entropy to create a parametric measure for satellite-based ecosystem diversity, integrating abundance and spectral distance.

Negative durotaxis: cell movement toward softer environments

The paper identifies negative durotaxis, where cells migrate toward softer environments, and shows that integrin adhesion and motor-clutch dynamics drive this behavior in glioblastoma and neurites.

The Biogeography of Fungal Communities Across Different Chinese Wine-producing Regions Associated with Environmental Factors and Spontaneous Fermentation Performance

This study analyzes fungal communities in Chinese Marselan wine fermentation across regions, finding that environmental factors significantly influence fungal composition and fermentation performance.

A red fluorescent protein with improved monomericity enables ratiometric voltage imaging with ASAP3

The paper develops a ratiometric voltage indicator by fusing an improved red fluorescent protein to ASAP3, enabling motion artifact-free voltage imaging in motile cells.

Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases

The paper designs a new class of protease inhibitors targeting coronavirus Mpro, identifying ML1000 as a potent inhibitor with low-nanomolar affinity and antiviral activity.

A Biodiversity Composition Map of California Derived from Environmental DNA Metabarcoding and Earth Observation

The paper integrates environmental DNA and Earth observation to create a biodiversity map of California, showing strong community-environment correlations and environmental filtering effects.

Different pattern of pre-existing SARS-COV-2 specific T cell immunity in SARS-recovered and uninfected individuals

The paper compares pre-existing SARS-CoV-2 specific T cell immunity in SARS-recovered and uninfected individuals, finding differential T cell immunodominance patterns.