MicrobiologybioRxiv
Genetic Engineering of Treponema pallidum subsp. pallidum, the Syphilis Spirochete
E. Romeis, L. Tantalo, N. Lieberman…·L. Giacani
This paper successfully genetically modifies Treponema pallidum by replacing a pseudogene with a kanamycin resistance cassette, enabling functional genetics studies of syphilis.
DOI 10.1371/journal.ppat.1009612