Q. Phung

Treponema pallidum subsp. pallidum with an Artificially Impaired TprK Antigenic Variation System is Attenuated in the Rabbit Model of Syphilis

This study creates a T. pallidum strain with impaired TprK antigenic variation and shows it is attenuated in a rabbit syphilis model.

HLApollo: A superior transformer model for pan-allelic peptide-MHC-I presentation prediction, with diverse negative coverage, deconvolution and protein language features.

HLApollo improves MHC-I peptide presentation prediction with a transformer model, showing better performance than existing methods and offering pan-allelic generalization.

SARS-CoV-2 variant of concern type and biological sex affect efficacy of molnupiravir in dwarf hamster model of severe COVID-19

This study evaluates molnupiravir efficacy against SARS-CoV-2 variants in different models, finding VOC-dependent efficacy and sex-based differences in dwarf hamsters.

Longitudinal accumulation of in vivo and in vitro-grown Treponema pallidum subsp. pallidum TprK variants in the presence and absence of immune pressure

This study shows that T. pallidum generates TprK sequence diversity both under immune pressure and in vitro without immune selection, highlighting the role of gene conversion in antigenic variation.

Genetic Engineering of Treponema pallidum subsp. pallidum, the Syphilis Spirochete

This paper successfully genetically modifies Treponema pallidum by replacing a pseudogene with a kanamycin resistance cassette, enabling functional genetics studies of syphilis.

In vivo generation of BK and JC polyomavirus defective viral genomes in human urine samples associated with higher viral loads

The paper identifies defective viral genomes (DVGs) in clinical urine samples of BK and JC polyomaviruses, showing their association with higher viral loads and genomic rearrangements.

Estimation of Full-Length TprK Diversity in Treponema pallidum subspecies pallidum

This study uses deep sequencing to characterize full-length TprK diversity in T. pallidum strains from human infections, revealing near-complete sequence divergence and estimating high antigenic variation potential.

SARS-CoV-2 ORF6 disrupts nucleocytoplasmic transport through interactions with Rae1 and Nup98

This paper shows SARS-CoV-2 ORF6 interacts with Rae1 and Nup98 to disrupt nucleocytoplasmic transport, reducing reporter expression and causing nuclear mRNA accumulation, more strongly than SARS-CoV ORF6.