Author

L. Wacheul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. L. Lafontaine· 2 shared A. Rogers· 1 shared A. Shpylovyi· 1 shared C. Heissenberger· 1 shared F. G. Ernst· 1 shared F. Nagelreiter· 1 shared I. Stocker· 1 shared J. A. Rollins· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

D. L. Lafontaine

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2 papers

Recent·Most cited

Nopp140-chaperoned 2'-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity

J. Bizarro, S. Deryusheva, L. Wacheul, V. Gupta, F. G. Ernst, D. L. Lafontaine, J. G. Gall, U. T. Meier

This study identifies CBs as the site of snRNA modification by scaRNPs, showing that Nopp140 and CK2 are critical for splicing fidelity and that CK2 inhibitors may affect splicing in diseases.

bioRxiv · Apr 29, 2021Cell Biology

The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans

C. Heissenberger, T. L. Krammer, J. A. Rollins, F. Nagelreiter, I. Stocker, L. Wacheul, A. Shpylovyi, S. Snow, J. Grillari, A. Rogers, D. L. Lafontaine, M. Schosserer

This study identifies NSUN-1 as an enzyme that methylates rRNA at position C2982 in C. elegans, showing that its depletion affects healthspan, oogenesis, and cuticle integrity.

bioRxiv · Mar 16, 2020Cell Biology