V. Gupta

HIF-1 activated by PIM1 assembles a pathological transcription complex and regulon that drives JAK2V617F MPN disease

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

Proteomic Profiling of Mesenchymal Stem Cell-Derived Extracellular Vesicles: Impact of Isolation Methods on Protein Cargo

This study compares protein cargo differences in mesenchymal stem cell-derived extracellular vesicles isolated by three methods, finding method-specific impacts on proteome composition and biological function.

The dCMP deaminase DCTD and the E3 ligase TOPORS are central mediators of decitabine cytotoxicity

This study identifies DCTD and TOPORS as key factors in decitabine cytotoxicity by showing their roles in DPC formation and repair.

A Novel AI-Designed Antimicrobial Peptide Synergistically Potentiates Aminoglycosides against Colistin- and Carbapenem-Resistant Acinetobacter baumannii

This study designs AI-generated antimicrobial peptides that synergize with aminoglycosides to combat colistin- and carbapenem-resistant Acinetobacter baumannii, showing potent antibacterial activity and biofilm eradication.

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

The paper shows that SARS-CoV-2 spike antibodies can enhance DENV2 infection in vitro and in vivo, suggesting potential for increased dengue severity in COVID-19 survivors.

Tunable PhenoCycler Imaging of the Murine Pre-Clinical Tumour Microenvironments

This study uses PhenoCycler imaging to analyze the tumor microenvironment in murine cancer models, revealing distinct TME features and cell-cell contact differences across cancer types.

A chromosome-scale assembly of Brassica carinata (BBCC) accession HC20 containing resistance to multiple pathogens and an early generation assessment of introgressions into B. juncea (AABB)

The paper presents a chromosome-scale genome assembly of B. carinata and assesses introgression potential into B. juncea for disease resistance.

The restriction factor pastrel is associated with host vigor, viral titer, and variation in disease tolerance during Drosophila C Virus infection

This study investigates the role of the Drosophila restriction factor pastrel in resistance and disease tolerance to DCV infection, finding its impact on viral titers, host survival, and fecundity.

Pathogen dependence and inter-individual variability of post-infection reproductive fitness in Drosophila melanogaster

This study investigates how bacterial infections affect reproductive fitness in Drosophila melanogaster, finding that pathogen identity predicts population-level responses but not individual variability, and that infected females that survive show reproductive output similar to uninfected controls.

Context-dependent triggering of STING-interferon signaling by CD11b agonists supports anti-tumor immunity in mouse models and human cancer patients

This study identifies how CD11b agonists trigger STING-interferon signaling in tumor-associated macrophages to enhance anti-tumor immunity in mouse models and human cancer patients.

Type I PRMTs and PRMT5 Inversely Regulate Post-Transcriptional Intron Detention

This study shows PRMTs inversely regulate intron retention post-transcriptionally through arginine methylation of Sm and CHTOP proteins.

Nopp140-chaperoned 2'-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity

This study identifies CBs as the site of snRNA modification by scaRNPs, showing that Nopp140 and CK2 are critical for splicing fidelity and that CK2 inhibitors may affect splicing in diseases.

Reliance on polyfunctional tissue leads to a reproduction-immunity tradeoff due to inherent constraint

The paper shows that in Drosophila, reproductively active females have reduced protein production capacity during infection, leading to a reproduction-immunity tradeoff.

Type I PRMTs and PRMT5 Independently Regulate Both snRNP Arginine Methylation and Post-Transcriptional Splicing

The paper investigates how Type I PRMTs and PRMT5 regulate splicing by analyzing transcriptomic changes and co-transcriptional splicing kinetics.

Comparative Genomics and Integrated Network Approach Unveiled Undirected Phylogeny Patterns, Co-mutational Hotspots, Functional Crosstalk and Regulatory Interactions in SARS-CoV-2

The paper analyzes SARS-CoV-2 genomic variations and host-pathogen interactions to identify mutational patterns, co-mutations, and functional implications in USA strains.

Evolutionary genetics of Drosophila melanogaster immunity: role of the X chromosome and sex-specific dominance

The paper investigates the role of the X chromosome in immune response evolution in Drosophila melanogaster and finds sex-specific dominance patterns in immunity-related alleles.

A subcellular atlas of Toxoplasma reveals the functional context of the proteome

This study maps the subcellular locations of thousands of proteins in Toxoplasma gondii to reveal their functional contexts and evolutionary adaptations.

Natural variation identifies a Pxy gene controlling root vascular organization and formation of nodules and lateral roots in Lotus japonicus

Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution

This study analyzes SARS-CoV-2 genomes from global isolates to reveal mosaic phylogeographical patterns and identify unique mutations associated with immune evasion mechanisms.

MS2-TRIBE evaluates protein-RNA interactions and nuclear organization of transcription by RNA editing

The paper evaluates protein-RNA interactions and nuclear RNA organization using MS2-TRIBE, showing TRIBE can edit nearby nascent transcripts and form RNA regulatory domains.

Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid

This study shows valproic acid corrects the folding and trafficking defect of the I1061T-NPC1 mutation, restoring cholesterol homeostasis and suggesting a potential therapeutic approach for Niemann-Pick type C disease.

BjuWRR1, a CC-NB-LRR gene identified in Brassica juncea, confers resistance to white rust caused by Albugo candida

The paper identifies and validates BjuWRR1, a CC-NB-LRR gene in Brassica juncea, as a resistance gene against white rust caused by Albugo candida through genetic transformation.

Extreme genetic signatures of local adaptation during plant colonization

The paper investigates genetic adaptations during the colonization of Japan by Lotus japonicus, identifying genomic regions and candidate genes associated with overwintering and flowering time traits.

Isolation and characterization of BpL1, a broad acting lytic bacteriophage against Brucella

The paper isolates and characterizes a broad-acting lytic bacteriophage (BpL1) against Brucella species, showing its lytic activity and stability under various conditions.

Non-linear disease tolerance curves reveal distinct components of host responses to viral infection

This study shows that non-linear models better capture host responses to viral infection than linear models, revealing sex-specific differences in tolerance mediated by G9a.

Costs and benefits of sub-lethal Drosophila C virus infection

This study investigates the physiological and behavioral effects of sub-lethal Drosophila C Virus infection on Drosophila melanogaster, finding significant fitness impacts that vary with host genotype, sex, and pathogen concentration.