Nanotopography reveals metabolites that maintain the immunosuppressive phenotype of mesenchymal stem cells
E. Ross, L.-A. Turner, A. Saeed, K. Burgess, G. Blackburn, P. Reynolds, J. Wells, J. Mountford, N. Gadegaard, M. Salmeron-Sanchez, R. Oreffo, M. Dalby
This study shows nanotopography can control MSC immunomodulatory capacity by modulating intracellular tension and oxidative glycolysis, and identifies bioactive metabolites that influence MSC function.
bioRxiv · Apr 29, 2019 · PreprintBioengineering