Author

R. Oreffo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Wells· 4 shared K. Burgess· 4 shared M. Salmeron-Sanchez· 4 shared M. Dalby· 3 shared M. Tsimbouri· 3 shared P. Childs· 3 shared D. Meek· 2 shared M. Vassalli· 2 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioengineering

J. Wells

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PEA polymer-coated nanotopography delivers solid-state BMP2, enhances mesenchymal stem cell adhesion, prevents bacterial biofilm formation and protects cells from quorum sensing virulence factors

L. Damiati, M. Tsimbouri, M. Ginty, V. Llopis-Hernandez, P. Childs, V. Jayawarna, Y. Xiao, K. Burgess, J. Wells, M. Sprott, D. Meek, P. Li, R. Oreffo, A. Nobbs, G. Ramage, , M. Dalby

bioRxiv · Sep 17, 2020 · PreprintBioengineering

Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering

W. Orapiriyakul, M. Tsimbouri, P. Childs, P. Campsie, J. Wells, M. M. Fernandez, K. Burgess, E. Tanner, M. Tassieri, D. Meek, M. Vassalli, M. Biggs, M. Salmeron-Sanchez, R. Oreffo, S. Reid, M. Dalby

This study shows that nanovibrational stimulation of MSCs induces ROS and low-level inflammation, mimicking natural bone healing, and uses this to design a 3D bone tissue scaffold.

bioRxiv · Apr 10, 2020Bioengineering

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

T. Hodgkinson, M. Tsimbouri, V. Llopis-Hernandez, P. Campsie, D. Scurr, P. Childs, D. Phillips, S. Donnelly, J. Wells, M. Salmeron-Sanchez, K. Burgess, M. R. Alexander, M. Vassalli, R. Oreffo, S. R. Reid, , M. J. Dalby

This study uses nanovibration to induce osteogenic differentiation in MSCs without exogenous growth factors, identifying cholesterol sulphate and fludrocortisone acetate as potent bioactive metabolites.

bioRxiv · Feb 7, 2020Bioengineering

Nanotopography reveals metabolites that maintain the immunosuppressive phenotype of mesenchymal stem cells

E. Ross, L.-A. Turner, A. Saeed, K. Burgess, G. Blackburn, P. Reynolds, J. Wells, J. Mountford, N. Gadegaard, M. Salmeron-Sanchez, R. Oreffo, M. Dalby

This study shows nanotopography can control MSC immunomodulatory capacity by modulating intracellular tension and oxidative glycolysis, and identifies bioactive metabolites that influence MSC function.

bioRxiv · Apr 29, 2019 · PreprintBioengineering