N. Gadegaard

CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge

Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM

This study investigates how integrin-ligand combinations affect cardiomyocyte adhesion, traction forces, and mechanosignalling in healthy and fibrotic ECM environments.

EFR3 and phosphatidylinositol 4-kinase IIIα regulate insulin-stimulated glucose transport and GLUT4 dispersal in 3T3-L1 adipocytes.

Nanotopography controls single-molecule mobility to determine overall cell fate

This study shows that nanotopography influences single-molecule mobility, which in turn affects cell fate by altering focal adhesion formation.

Customizable, engineered substrates for rapid screening of cellular cues

The paper introduces a customizable multiwell array for high-throughput screening of biophysical cues, demonstrating its effectiveness in assessing cell responses to topography and rigidity.

Nanotopography reveals metabolites that maintain the immunosuppressive phenotype of mesenchymal stem cells

This study shows nanotopography can control MSC immunomodulatory capacity by modulating intracellular tension and oxidative glycolysis, and identifies bioactive metabolites that influence MSC function.

Predicting gene expression using morphological cell responses to nanotopography

The paper predicts gene expression changes induced by nanotopography using a morphome-based Bayesian model.

Controlling fluid flow to improve cell seeding uniformity

This paper introduces a device to improve cell seeding uniformity by controlling fluid flow, reducing variability in cell density and improving differentiation outcomes in human embryonic stem cells.