Lara S. U. Schwab

The paper analyzes the antigenic evolution of influenza B virus hemagglutinin over 8 decades, identifying epistatic networks that balance antigenic novelty with viral fitness.

The paper quantifies pre-existing human B cell responses to avian influenza H5 and H7 hemagglutinins and shows limited boosting by seasonal vaccines.

The paper shows that early life exposure to influenza B virus influences cross-reactivity and susceptibility to future isolates, explaining lineage-specific infection patterns across birth cohorts.

This study shows that influenza B virus dissemination from the upper respiratory tract to the lungs in mice is restricted by the interferon response and that TRT priming provides better protection than URT priming.