Marios Koutsakos

This study shows that vaccine strain selection and prior immunity influence antibody breadth against avian H5 hemagglutinin in mice.

The paper analyzes the antigenic evolution of influenza B virus hemagglutinin over 8 decades, identifying epistatic networks that balance antigenic novelty with viral fitness.

The paper examines pre-existing antibodies against avian H5 influenza A viruses in individuals born between 1928-1999, showing variations based on childhood exposure and birth year.

This study compares NA-specific antibody titres in serum and plasma using ELLA and ELISA, finding discrepancies and recommending serum for standardized assays.

The paper quantifies pre-existing human B cell responses to avian influenza H5 and H7 hemagglutinins and shows limited boosting by seasonal vaccines.

This paper demonstrates that Triton-X 100-treated virus-based ELLA overcomes HA interference in IBV, revealing discordant antigenic evolution between HA and NA.

The paper shows that early life exposure to influenza B virus influences cross-reactivity and susceptibility to future isolates, explaining lineage-specific infection patterns across birth cohorts.

This study shows that influenza B virus dissemination from the upper respiratory tract to the lungs in mice is restricted by the interferon response and that TRT priming provides better protection than URT priming.