Laura Bell

Molecular and Structural Basis of Cardiac Remodelling in Niemann-Pick Type C

This study identifies cardiac involvement in Niemann-Pick type C through ECG abnormalities, fibrosis, and transcriptomic changes in patients and Npc1-/- mice.

Investigating the role of cortical microglia in a mouse model of viral infection-induced seizures

The paper investigates how cortical microglia respond to TMEV infection by analyzing purinergic signaling, cytokine levels, and receptor expression across brain regions.

Lysosomal calcium signalling contributes to the acute α-adrenergic response via calcium-stimulated adenylyl cyclase 1 and 8

This study shows that lysosomal calcium signaling via NAADP and calcium-stimulated adenylyl cyclase 1 and 8 contributes to the acute α-adrenergic response in atrial myocytes.

APOE4 expression confers a mild, persistent reduction in neurovascular function in the visual cortex and hippocampus of awake mice

This study shows APOE4 mice have reduced vascular responsiveness and increased neuronal calcium signals in the visual cortex and hippocampus, suggesting APOE4 alters neurovascular function without causing severe deficits.

Hippocampus has lower oxygenation and weaker control of brain blood flow than cortex, due to microvascular differences

The paper shows the hippocampus has lower oxygenation and weaker blood flow control than cortex due to vascular differences, linking this to its vulnerability in neurological diseases.