NeurosciencebioRxivPreprint
Glucocorticoids desensitize hypothalamic CRH neurons to norepinephrine and somatic stress activation via rapid nitrosylation-dependent regulation of α1 adrenoreceptor trafficking
Grant L. Weiss, Laura M. Harrison, Zhiying Jiang…·Jeffrey G. Tasker
This study shows glucocorticoids rapidly desensitize CRH neurons to norepinephrine by regulating α1 adrenoreceptor trafficking through nitrosylation and endocytosis.
DOI 10.1101/2024.07.29.605704