NeurosciencebioRxivPreprint
The impact of Mmu17 non-Hsa21 orthologous genes in the Ts65Dn mouse model of Down syndrome: the "gold standard" revisited
Fayçal Guedj, Elise Kane, Lauren A. Bishop…·Diana W. Bianchi
This paper compares the Ts65Dn and Ts66Yah mouse models of Down syndrome, showing that trisomy of non-orthologous Mmu17 genes worsens the phenotype and may explain failed human therapy translations.
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