Cancer BiologybioRxivPreprint
PHGDH is a targetable driver of PDAC progression
Yumi Kim, Le Jin Sun, Matthew Long…·Gina M. DeNicola
This study identifies PHGDH as a driver of PDAC progression by maintaining glutamine metabolism and mTOR signaling, revealing a therapeutic vulnerability to glutamine antagonism in PHGDH-deficient tumors.