Cancer BiologybioRxiv
Clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction
Paul Deveau, Leo Colmet Daage, Derek Oldridge…·Valentina Boeva
The paper introduces QuantumClone, a method for clonal reconstruction in cancer that accounts for variant allele frequencies and genotypes, and applies it to neuroblastoma samples to identify recurrently altered pathways in different clonal populations.
DOI 10.1093/bioinformatics/bty016