A bovine-derived influenza A virus (H5N1) shows efficient replication in well-differentiated human nasal epithelial cells at the temperature of the upper airways
Étori Aguiar Moreira, Samuel Constant, Charlene Constant…·Gert Zimmer
This study shows that a bovine-derived H5N1 virus replicates efficiently in human nasal epithelial cells at both 37°C and 33°C, with specific mutations enhancing replication at lower temperatures.