Nan Li

APP functions at the endomembrane system

This study investigates APP's role in the endomembrane system, showing its impact on FE65 localization, ATF4 levels, and autophagy regulation.

The cellular and genetic basis of inflorescence divergence between maize and teosinte

This study identifies cellular and genetic changes in maize and teosinte ears, showing how cytokinin signaling and transcription factor expression differences drive cob thickening and increased kernel number during domestication.

Allogeneic CRISPR-Engineered CAR-T Cells Drive Potent Antitumor Activity in Solid Tumors

This study develops allogeneic CRISPR-engineered CAR-T cells targeting GPC2 and GPC3, showing potent antitumor activity in solid tumors with repeated dosing and no toxicity.

PhyloSOLID: Robust phylogeny reconstruction from single-cell data despite inherent error and sparsity

PhyloSOLID improves phylogenetic reconstruction from single-cell data by addressing error and sparsity, achieving better accuracy than existing methods.

Prophylactic Lipoxin A4 Attenuates Clostridioides difficile Infection by Augmenting Epithelial Barrier and Resolving Inflammation

This study shows that prophylactic Lipoxin A4 reduces Clostridioides difficile infection by improving epithelial barrier function and reducing inflammation in both in vitro and mouse models.

SEAD: an augmented reference panel with 22,134 haplotypes boosts the rare variants imputation and GWAS analysis in Asian population

The paper introduces SEAD, an Asian reference panel that improves rare variant imputation and GWAS analysis, identifying a novel association between SNTG1 and hip BMD.

Molecular diagnosis of non-syndromic hearing loss patients using a stepwise approach

This study uses a stepwise approach combining multiplex PCR and exome sequencing to diagnose 64% of non-syndromic hearing loss patients, identifying 59 molecular diagnoses from 92 unrelated cases.

Genomic analyses of 10,376 individuals provides comprehensive map of genetic variations, structure and reference haplotypes for Chinese population

The paper presents genomic analyses of 10,376 Chinese individuals, identifying novel genetic variations and providing a reference haplotype map, along with an imputation server for improved accuracy.

ZmCOL3, a CCT-domain containing gene affects maize adaptation as a repressor and upstream of ZmCCT

The paper identifies ZmCOL3 as a flowering time repressor in maize that delays flowering by transactivating ZmCCT or interfering with the circadian clock, contributing to adaptation from tropical to temperate regions.

Revealing missing isoforms encoded in the human genome by integrating genomic, transcriptomic and proteomic data

The paper identifies 31,566 novel protein-coding transcripts and estimates the total human protein-coding transcripts to be over 200,000 by integrating genomic, transcriptomic, and proteomic data.