Lu Yang

Proximity-mapped whole-genome sequencing for characterization of repeat expansions and variants in highly homologous genomic regions

This study evaluates TruPath Genome's ability to characterize repeat expansions and variants in complex genomic regions using archived DNA samples, showing consistent results with orthogonal methods.

Early identification of rare disease using deep phenotyping of electronic health records

This study uses machine learning on electronic health records to identify rare genetic disorders early, achieving up to 89% early detection with over a year lead time for some conditions.

Estrogen interactions with breast cancer risk variants in regulatory DNA

The paper identifies estrogen-modulated SNVs associated with breast cancer risk and shows their interaction with reproductive factors using polygenic risk scores.

PARP16 is a Druggable Regulator of Ribosome MARylation and Protein Homeostasis in Ovarian Cancer Cells

This study investigates PARP16's role in ovarian cancer by showing that inhibiting it with DB008 disrupts ribosome MARylation, impairs protein homeostasis, and reduces tumor growth.

Genetic association studies using disease liabilities from deep neural networks

This paper introduces two methods for GWAS using disease liabilities from deep neural networks, identifying more loci and improving prediction of newly diagnosed cases.

Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation

The paper shows that larval neurons upregulate Prospero protein through alternative polyadenylation and Syncrip-mediated mRNA stabilization.

CytoCensus: mapping cell identity and division in tissues and organs using machine learning

CytoCensus is a machine learning tool for automated cell detection and division quantification in complex 3D tissues, outperforming existing software in accuracy and speed.

Single Molecule Fluorescence In Situ Hybridisation For Quantitating Post-Transcriptional Regulation In Drosophila Brains

This paper applies single-molecule FISH to study post-transcriptional regulation in Drosophila brains by analyzing mRNA distributions and co-visualizing transcripts and proteins.

miR-200c Suppresses Stemness And Increases Cellular Sensitivity To Trastuzumab In HER2+ Breast Cancer

This study shows miR-200c reduces stemness and enhances trastuzumab sensitivity in HER2+ breast cancer cells and their stem-like populations.

Imp/Syp Temporal Gradients Govern Decommissioning Of Drosophila Neural Stem Cells

The paper shows that Imp and Syp RNA-binding protein gradients control the timing of Drosophila neuroblast decommissioning by regulating Prospero accumulation and mediator complex activity.