Lu Zhang

This study identifies 5-methyl-3'-dUTP as a nucleoside analogue that effectively terminates RNA chains and resists SARS-CoV-2 exoribonuclease proofreading.

AB-Gen uses reinforcement learning and a generative pre-trained Transformer to design antibody sequences with multiple desirable properties, improving success rates over traditional methods.

This study reports the X-ray crystal structures of E. coli RNA polymerase complexes with DksA and ppGpp, revealing how ppGpp enhances DksA's inhibition of transcription initiation.