Author

Lucas Aragao

Hospital for Sick Children

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Ahmed M. AmaniD· 1 shared Alexandria DeCarlo· 1 shared Amarine Trolat· 1 shared Brian L. GudenasiD· 1 shared Carolina Fernandes da SilvaiD· 1 shared Carolina Nör· 1 shared Deborah Termini· 1 shared Dénis Reynaud· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Ahmed M. AmanORCID

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1 paper

Recent·Most cited

Cancer BiologyCell Reports MedicinePeer-reviewedJun 24, 2025

Targeting synthetic lethality between non-homologous end joining and radiation in very high-risk SHH medulloblastoma

Alexandria DeCarlo, Graham Dickson and Hugh MacLeod, Carolina Fernandes da Silva…·Vijay Ramaswamy

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

6 citations

mousegenetic perturbation / CRISPR

𝕏 PostBluesky