Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewed
SH2scan: Mapping SH2 domain-ligand binding selectivity for inhibitors and degraders
Luis M. Gonzalez Lira, Jennifer K. Wolfe-Demarco, Alexander Michael Clifford…·Jean A. Bernatchez
SH2scan quantifies ligand-SH2 domain interactions across >80% of targets, revealing binding selectivity and KDs to aid in designing selective inhibitors and degraders.
DOI 10.1021/acs.jmedchem.5c02613