Cell BiologybioRxivPreprint
Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation
S. Solier, S. Muller, T. Caneque…·R. Rodriguez
The paper identifies a copper-signaling pathway involving CD44 and mitochondrial copper(II) that drives inflammation and cell plasticity, and shows a metformin-based drug reduces inflammation in infection models.
DOI 10.1101/2022.03.29.486253