MicrobiologybioRxiv
Rapid Loss of CD4 T Cells by Pyroptosis During Acute SIV Infection in Rhesus Macaques
X. He, M. Aid, J. Ventura…·D. H. Barouch
This study identifies pyroptosis as the main cause of CD4 T cell loss in acute SIV infection in rhesus macaques, with IFI16 upregulation linked to viral loads and cell depletion.
DOI 10.1128/jvi.00808-22