X. He

Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma

This study uses single-cell RNA sequencing to identify unique cell clusters and immunosuppressive features in cervical adenocarcinoma compared to squamous cell carcinoma.

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Identifying essential genes in Schaalia odontolytica using a highly-saturated transposon library

This study identifies essential genes in Schaalia odontolytica using high-throughput transposon insertion sequencing.

Identification of P-type ATPase as a bacterial transporter for host-derived small RNA

This study identifies a bacterial P-type ATPase transporter, PtaT, that specifically binds and mediates the uptake of host-derived tsRNAs in Fusobacterium nucleatum.

Adhesive interactions within microbial consortia can be differentiated at the single-cell level through expansion microscopy

This study uses expansion microscopy to differentiate adhesive interactions between microbial cells in biofilms at the single-cell level.

A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development

This paper introduces a novel large-scale EV production strategy with upstream fed-batch suspension cell culture and downstream chromatographic purification for clinical applications.

Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants

This study identifies miR-146a as a key regulator of the foreign body response to biomaterial implants, showing its role in macrophage function, fibrosis, and FBGC formation.

Circadian control of kidney regeneration via Lima1-mediated regulation of EMT

This study investigates the role of circadian clock genes in kidney regeneration using zebrafish, finding that per1 and nr1d1 promote regeneration by repressing lima1a, which regulates EMT.

Genome-Wide Identification and Comprehensive Analysis of the SBT Gene Family in Soybean (Glycine max)

This study identifies and analyzes the SBT gene family in soybean, revealing 118 members grouped into six subgroups and providing insights into their expression and regulatory features.

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

MICROCOSM FABRICATION PLATFORM FOR LIVE MICROSCOPY OF PLANT-SOIL SYSTEMS

The paper develops a microcosm fabrication platform for live microscopy of plant-soil systems, enabling controlled water content and observation of root-soil interactions.

Enhanced Antibody Response to the Conformational Non-RBD Region via DNA Prime-Protein Boost Elicits Broad Cross-Neutralization Against SARS-CoV-2 Variants

This study shows that DNA prime-protein boost elicits enhanced antibodies against non-RBD regions of SARS-CoV-2, improving cross-neutralization against variants in mice.

Mesenchymal stem cell-derived extracellular vesicles attenuate symptoms in dextran sodium sulfate-induced ulcerative colitis mouse model

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce symptoms in a dextran sulfate sodium-induced ulcerative colitis mouse model by repairing colon mucosa and reducing macrophage infiltration.

Sustaining healthy long-term host-microbiome interactions in a physiologically relevant dynamic gingival tissue model

This paper develops a 3D gingival model co-cultured with patient-derived microbiomes to study host-microbiome interactions and tissue homeostasis.

Therapeutic targeting of KRAS mutation-driven tumorigenesis by extracellular vesicles loaded with small interfering RNA

This study demonstrates that extracellular vesicles loaded with KRAS-targeting siRNA can inhibit tumor growth in mouse models, both intratumorally and intravenously.

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

Persistent enrichment of multidrug resistant Klebsiella in oral and nasal communities during long-term starvation

This study shows that Klebsiella outcompetes other microbes in oral and nasal communities during starvation, contributing to its persistence and potential pathogenicity.

A 3-component module maintains sepal flatness in Arabidopsis

The paper identifies a 3-component module involving VIP4, ARF3, and VANGUARD1 that maintains sepal flatness in Arabidopsis by regulating cell wall stiffness and growth balance.

DNA origami assembled spheroid for evaluating cytotoxicity and infiltration of chimeric antigen receptor macrophage (CAR-M)

This study evaluates the cytotoxicity and infiltration of CAR-M using 3D tumor spheroids assembled with DNA origami, showing enhanced invasion and killing capacity in 3D models.

Development of attenuated coxsackievirus B3 vectored intranasal pre-emptive pan-coronavirus vaccine

The paper designs an intranasal pan-coronavirus vaccine using epitopes from SARS-CoV-2 and zoonotic coronaviruses, showing immune responses in mice but needing further cross-reactivity testing.

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase transition potential

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

A spatial human thymus cell atlas mapped to a continuous tissue axis

The paper maps the spatial organization of the human thymus across developmental stages using a multimodal atlas and identifies key cellular and molecular features of T cell development.

A novel rotavirus reverse genetics platform supports flexible insertion of exogenous genes and enables rapid development of a high-throughput neutralization assay

This paper develops a rotavirus reverse genetics platform enabling exogenous gene insertion and a high-throughput neutralization assay to study immune responses.

Comparative single-cell regulome reveals evolutionary innovations in neural progenitor cells during primate corticogenesis

The paper compares single-cell regulomes of macaque and mouse neural progenitors with human data to identify evolutionary changes in cortex development.

Episymbiotic bacterium induces intracellular lipid droplet production in its host bacteria

This study investigates the interaction between Saccharibacteria TM7x and its host XH001, revealing TM7x-induced lipid droplet formation in XH001 and its protective role under stress.

Harnessing extracellular vesicles for efficient siRNA delivery in vitro and in vivo

This study develops an efficient siRNA delivery system using extracellular vesicles, demonstrating effective gene silencing in vitro and tumor growth inhibition in vivo.

Contribution of carbon inputs to soil carbon accumulation cannot be neglected

The paper challenges the conclusion that microbial carbon use efficiency is the main driver of soil carbon storage, highlighting potential biases in previous analyses.

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

A conserved and druggable pocket in class B G protein coupled receptors for orally active small molecule agonists

This study identifies a conserved binding pocket in class B GPCRs that enables small molecule agonists like PCO371 to activate G proteins without triggering arrestin signaling.

Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.