M. A. Seeger

The paper uses deep mutational scanning to analyze the structure-function relationship of the EfrCD drug efflux pump, revealing how mutations affect drug efflux and identifying mutations that convert it into a drug importer.

The paper uses cryo-EM to determine structures of the LptDE transporter complex with Pro-Macrobodies, revealing partially and fully opened states of the transporter during LPS translocation.

This paper reports the rapid in vitro selection of sybodies targeting the SARS-CoV-2 receptor-binding domain, identifying potent inhibitors with ACE2 blocking activity and potential for therapeutic development.

This study uses a synthetic antibody to determine the structure and mechanism of an ABC exporter's extracellular gate, showing its role in ATPase activity and transport.

This study develops a synthetic nanobody platform to generate conformation-specific binders for membrane proteins, overcoming limitations of traditional immunization methods.