Author

M. Botte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Bucher· 3 shared M. Chami· 3 shared M. Hennig· 3 shared H. Stahlberg· 2 shared N. Bocquet· 2 shared R. K. Y. Cheng· 2 shared A. Becker· 1 shared A. Brockmann· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBiochemistry

D. Bucher

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Author profile →

3 papers

Recent·Most cited

Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 reveal a novel binding site for positive modulators

M. Botte, S. Huber, D. Bucher, J. K. Klint, D. Rodriguez, L. Tagmose, M. Chami, R. K. Y. Cheng, M. Hennig, W. Abdul Rahman

The paper determines high-resolution Cryo-EM structures of the human Kv3.1 channel, both apo and ligand-bound, revealing a novel binding site for positive modulators.

bioRxiv · Jul 13, 2021 · PreprintBiochemistry

Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies

M. Botte, D. Ni, S. Schenck, I. Zimmermann, M. Chami, N. Bocquet, P. Egloff, D. Bucher, M. Trabuco, R. K. Y. Cheng, J. D. Brunner, M. A. Seeger, H. Stahlberg, M. Hennig

The paper uses cryo-EM to determine structures of the LptDE transporter complex with Pro-Macrobodies, revealing partially and fully opened states of the transporter during LPS translocation.

bioRxiv · Mar 23, 2021 · PreprintBiochemistry

Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation

M. Botte, A. K. C. Ulrich, R. Adaixo, D. Gnutt, A. Brockmann, D. Bucher, M. Chami, N. Bocquet, U. Ebbinghaus-Kintscher, V. Puetter, A. Becker, U. Egner, H. Stahlberg, M. Hennig, S. J. Holton

This paper reports the cryo-EM structure of hTRPV4 in an open conformation induced by 4-PDD agonist, revealing molecular mechanisms of activation and providing a template for inhibitor design.

bioRxiv · Oct 13, 2020 · PreprintMolecular Biology