NeuroscienceCell Death and DiseasePeer-reviewed
Cytoplasmic accumulation of a splice variant of hnRNP A2/B1 contributes to FUS-associated toxicity in a mouse model of ALS
Simona Rossi, Martina Milani, Ilaria Della Valle…·Mauro Cozzolino
This study shows that FUS-induced splicing changes lead to cytoplasmic accumulation of hnRNP A2b/B1 splice variants, promoting stress granule formation and motor neuron toxicity in a mouse model of ALS.
6 citations