ImmunologybioRxivPreprint
Inhibition of 2-Hydroxyglutrate Elicits Metabolic-reprograming and Mutant IDH1 Glioma Immunity
P. Kadiyala, S. V. Carney, J. C. Gauss…·M. Castro
This study shows that inhibiting 2-hydroxyglutarate in mIDH1 gliomas with ATRX/TP53 inactivation improves survival and induces anti-tumor immunity through immunological memory and reduced T-cell exhaustion.
DOI 10.1101/2020.05.11.086371