Screening of clustered regulatory elements reveals functional cooperating dependencies in Leukemia.
S. Benbarche, C. K. Lopez, E. Salataj, C. Thirant, M.-C. Laiguillon, Z. Aid, S. Lecourt, M. Antonini, B. Pardieu, A. Petit, A. Puissant, J. Chaumeil, T. Mercher, C. Lobry
The paper identifies co-regulated genes in leukemia using CRISPRi screening of super-enhancer regions, showing that combined inhibition of KIT and PDGFRA synergizes to impair leukemia cell growth.
bioRxiv · Jun 24, 2019 · PreprintCancer Biology