Cancer BiologybioRxivPreprint
Screening of clustered regulatory elements reveals functional cooperating dependencies in Leukemia.
S. Benbarche, C. K. Lopez, E. Salataj…·C. Lobry
The paper identifies co-regulated genes in leukemia using CRISPRi screening of super-enhancer regions, showing that combined inhibition of KIT and PDGFRA synergizes to impair leukemia cell growth.