BiophysicsbioRxiv
Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysis
C. J. Buchanan, B. Gaunt, P. J. Harrison…·B. G. Davis
This paper introduces uSTA, an NMR method to analyze protein-ligand interactions, revealing SARS-CoV-2 spike binds sialoside sugars via the NTD and showing variants-of-concern lose this binding.
DOI 10.1126/science.abm3125