B. G. Davis

Distributable, Metabolic PET Reporting of Tuberculosis

This paper introduces [18F]FDT, a PET tracer that specifically images Mycobacterium tuberculosis lesions and monitors treatment, enabling global access through a simple synthesis method from [18F]FDG.

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

Haptenic adducts of beta-lactam antibiotics elicit antibody responses with narrow clonality and specificity

This study investigates how penicillin G forms immunogenic adducts on proteins and elicits specific antibody responses in mice, revealing clonal dominance and limited cross-reactivity with other beta-lactam antibiotics.

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

The paper engineers nanobody interfaces to improve crystal reliability and diversity, resulting in better diffraction and multiple polymorphs.

Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysis

This paper introduces uSTA, an NMR method to analyze protein-ligand interactions, revealing SARS-CoV-2 spike binds sialoside sugars via the NTD and showing variants-of-concern lose this binding.

Intact nucleosomal context enables chromodomain reader MRG15 to distinguish H3K36me3 from -me2

The paper shows MRG15 distinguishes H3K36me3 from H3K36me2 in intact nucleosomes, revealing a methyl-switch mechanism dependent on DNA backbone interactions.

Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design

This paper determines the structures of DPAGT1 with substrates and inhibitors, revealing catalytic mechanisms and disease-causing mutations, and designs non-toxic antibiotics for tuberculosis.