Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3
C. E. Rowland, H. Newman, T. T. Martin, R. Dods, N. Bournakas, J. M. Wagstaff, N. Lewis, S. J. Stanway, M. Balmforth, C. Kessler, K. van Rietschoten, D. Bellini, D. I. Roper, A. J. Lloyd, C. G. Dowson, , M. J. Dawson
This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.
bioRxiv · Mar 20, 2024 · PreprintBiochemistry