Author

D. I. Roper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

A. J. Lloyd· 2 shared C. G. Dowson· 2 shared A. C. Cuming· 1 shared A. J. Dowson· 1 shared A. S. Punekar· 1 shared C. W. G. Fishwisk· 1 shared D. Bellini· 1 shared D. J. Scott· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersEvolutionary Biology

A. J. Lloyd

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Author profile →

3 papers

Recent·Most cited

Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

J. Li, Y. He, X. Xu, M. Alcorlo, J. Shi, S. Naskar, N. Briggs, D. I. Roper, J. A. Hermoso, L.-T. Sham, M. Luo

This study presents structural and biochemical analysis of E. coli FtsEX complex, revealing ATP's role in stabilization and EnvC-mediated activation of PG hydrolysis.

bioRxiv · Jan 16, 2024 · PreprintMicrobiology

Plant peptidoglycan precursor biosynthesis: Conservation between moss chloroplasts and Gram negative bacteria

A. J. Dowson, A. J. Lloyd, A. C. Cuming, D. I. Roper, L. Frigerio, C. G. Dowson

The paper identifies conserved peptidoglycan biosynthesis intermediates in moss chloroplasts and demonstrates D,L-DAP incorporation by a moss enzyme similar to Gram-negative bacteria.

Plant Physiology · Apr 26, 2022Peer-reviewedEvolutionary Biology

Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

R. Cain, R. Salimaraj, A. S. Punekar, D. Bellini, C. W. G. Fishwisk, L. Czapleski, D. J. Scott, G. Harris, C. G. Dowson, A. J. Lloyd, D. I. Roper

The paper identifies small molecule inhibitors that selectively target bacterial seryl-tRNA synthetases over human homologues using structure-based drug discovery.

bioRxiv · Mar 22, 2019Biochemistry