Author

A. J. Lloyd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Organism:E. coli· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

C. G. Dowson· 3 shared D. I. Roper· 3 shared D. Bellini· 2 shared A. C. Cuming· 1 shared A. J. Dowson· 1 shared A. S. Punekar· 1 shared A. York· 1 shared C. Dowson· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

C. G. Dowson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3

C. E. Rowland, H. Newman, T. T. Martin, R. Dods, N. Bournakas, J. M. Wagstaff, N. Lewis, S. J. Stanway, M. Balmforth, C. Kessler, K. van Rietschoten, D. Bellini, D. I. Roper, A. J. Lloyd, C. G. Dowson, , M. J. Dawson

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.

bioRxiv · Mar 20, 2024 · PreprintBiochemistry

Plant peptidoglycan precursor biosynthesis: Conservation between moss chloroplasts and Gram negative bacteria

A. J. Dowson, A. J. Lloyd, A. C. Cuming, D. I. Roper, L. Frigerio, C. G. Dowson

The paper identifies conserved peptidoglycan biosynthesis intermediates in moss chloroplasts and demonstrates D,L-DAP incorporation by a moss enzyme similar to Gram-negative bacteria.

Plant Physiology · Apr 26, 2022Peer-reviewedEvolutionary Biology

Structure-based modelling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant that functions at the cytoplasmic membrane interface

A. York, A. J. lloyd, C. I. del Genio, J. Shearer, K. Hinxman, K. Fritz, V. Fulop, S. Khalid, C. Dowson, D. Roper

The paper models MurM's structure and dynamics to show its interaction with phospholipids and Lipid II, revealing its role in penicillin resistance in Streptococcus pneumoniae.

bioRxiv · Jun 18, 2020Biochemistry

Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

R. Cain, R. Salimaraj, A. S. Punekar, D. Bellini, C. W. G. Fishwisk, L. Czapleski, D. J. Scott, G. Harris, C. G. Dowson, A. J. Lloyd, D. I. Roper

The paper identifies small molecule inhibitors that selectively target bacterial seryl-tRNA synthetases over human homologues using structure-based drug discovery.

bioRxiv · Mar 22, 2019Biochemistry