Author

C. G. Dowson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. J. Lloyd· 2 shared D. I. Roper· 2 shared A. Aimon· 1 shared A. Bradley· 1 shared A. C. Cuming· 1 shared A. Douangamath· 1 shared A. J. Dowson· 1 shared A. Plotnikov· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersEvolutionary Biology

A. J. Lloyd

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Author profile →

3 papers

Recent·Most cited

Plant peptidoglycan precursor biosynthesis: Conservation between moss chloroplasts and Gram negative bacteria

A. J. Dowson, A. J. Lloyd, A. C. Cuming, D. I. Roper, L. Frigerio, C. G. Dowson

The paper identifies conserved peptidoglycan biosynthesis intermediates in moss chloroplasts and demonstrates D,L-DAP incorporation by a moss enzyme similar to Gram-negative bacteria.

Plant Physiology · Apr 26, 2022Peer-reviewedEvolutionary Biology

Rapid covalent-probe discovery by electrophile fragment screening

e. resnick, A. Bradley, J. Gan, A. Douangamath, T. Krojer, R. Sethi, A. Aimon, G. Amitai, D. Belini, J. Bennett, M. Fairhead, O. Fedorov, P. P. Geurink, J. Guo, A. Plotnikov, , N. London

This study develops a method for discovering covalent probes using electrophile fragment screening and identifies selective inhibitors for OTUB2 and NUDT7.

Journal of the American Chemical Society · May 7, 2019Peer-reviewedBiochemistry

Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

R. Cain, R. Salimaraj, A. S. Punekar, D. Bellini, C. W. G. Fishwisk, L. Czapleski, D. J. Scott, G. Harris, C. G. Dowson, A. J. Lloyd, D. I. Roper

The paper identifies small molecule inhibitors that selectively target bacterial seryl-tRNA synthetases over human homologues using structure-based drug discovery.

bioRxiv · Mar 22, 2019Biochemistry